Upcoming
Events
Recent Publications
Knoblaugh S, Treuting P, Linford N, Morton J, Rabinovitch P,
Ladiges W. Attenuation of age-related pathology in mitochondrial
catalase transgenic mice. In preparation.
Botta D, Shi S, White CC, Dabrowski MJ, Keener CL,
Srinouanprachanh SL, Farin FM, Ware CB, Ladiges, WC, Pierce RH, Tsai SY, O-Malley
BW, Fausto N, and Kavanagh TJ. Acetaminophen induced liver injury is
attenuated in glutamate-cysteine liagase transgenic mice. Submitted.
McConnachie LA, Hudson FN, Ware CB, Ladiges WC, Fernandez C,
Mohar I, Chatterton-Kirchmeier S, White CC, Pierce RH, and Kavanagh TJ.
Glutamate-cysteine ligase null mice are hypersensitive to
acetaminophen-induced hepatotoxicity. Submitted.
Moore-Sanders G, Knoblaugh S, Ladiges W. Insulin resistance
in Wrn null mice. Submitted.
Ladiges W. Variation in the DNA repair gene XRCC1 and
implications of cancer. Oncogene, in press.
Schriner SE, Linford NJ, Martin GM, Treuting P, Wolf N,
Ogburn GE, Ladiges WC, Emond M, Wallace D, Rabinovitch P. Overexpression of
mitochondrial-targeted catalase extends murine life span. Science. 2005
May 5; [Epub ahead of print].
MacAuley A, Ladiges WC. Approaches to determine clinical significance of
genetic variants. Mutation Research. 2005 Jun 3;573(1-2):205-20.
Weiss JM, Goode EL, Ladiges W, Ulrich CM. Polymorphic
variation in hOGG1 and risk of cancer: A review of the functional and epidemiological
literature. Mol Carcinog. 2005 Mar;42(3):127-41.
Ladiges WC, Knoblaugh SE, Morton JF, Korth MJ,
Sopher BL, Baskin CR, MacAuley A, Goodman AG, LeBoeuf RC, Katze MG.. Pancreatic
ß cell failure and diabetes in mice with a deletion mutation of the endoplasmic
reticulum stress response gene P58IPK. Diabetes. 2005 Apr; 54(4):1074-81.
Ladiges W, Kemp C,
Packenham J, Velazquez J. Human gene variation: From
SNPs to phenotypes. Mutation Res, 545(1-2):131-9,
2004.
Ware C, Siverts L,
Nelson A, Morton J, Ladiges W. Utility of a C57BL/6
ES cell line versus 129 ES cell lines for targeted
mutations in mice. Transgenics, 12(6):743-6,
2003.
Ladiges W, Wiley
J, MacAuley A. Polymorphisms in the DNA repair gene
XRCC1 and age-related disease. Mechanisms of Ageing
and Development, 124: 27-32, 2003.
Rubin C, Knoblaugh
S, and Ladiges W. Phenotypic Characterization of Genetically
Engineered Laboratory Animals. In: Handbook
of Laboratory Animal Science, Vol 1: Selection and
Handling of Animals in Biomedical Research, Van Hoosier
et al Ed. 10:206-232, 2003.
