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Available Mouse
Lines
The Mutant
Mouse Regional Resource Center (MMRRC) exists
to serve the research community by preserving biomedically
valuable mouse strains and distributing these strains
to the research community for internal, non-commercial
research purposes.
| Pkrkr Overexpression
Model |
MMRRC
Strain ID: 0132-H/M
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| This is a biochemical
model for looking at translational events
in protein synthesis, including the following
mechanistic processes: muscle development
and function, biology of aging, heat shock,
viral infection, stress-induced apoptosis,
and cancer in relation to selective inhibition
of protein synthesis and translation. |
| Genotype: |
Random integration of human
PKR cDNA under control of the CMV promoter.
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| Phenotype: |
Spleen cells are resistant
to apoptosis when treated with Actinomycin
D and show a decrease in proliferation in
response to Concanavalin A. |
| Primary Citation: |
Ladiges W, Morton J, Hopkins
H, Wilson R, Filley G, Ware C, Gale M.
Expression of Human PKR Protein Kinase in
Transgenic Mice. Journal of Interferon
and Cytokine Research (2002) 22: 329 –
334 |
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Medline Accession:
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#
12034040 |
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| WRN Overexpression
Model |
MMRRC
Strain ID: 0130-H/M
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| This
is a novel mouse model for studying Werner
Syndrome and other age-related disorders. |
| Genotype: |
Random integration
of human cDNA containing a single amino
acid substitution at position 577 (K577M)
in the recombinant human WRN protein.
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| Phenotype: |
Model shows
hypersensitivity to 4-nitroquinoline-1-oxide,
reduced replicative potential, and reduced
expression of the endogenous WRN protein.
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| Primary Citation: |
lan wang, charles E. Ogburn,
Carol B. Ware, Warren C. Ladiges, Hagop
Youssoufian, George M. Martin, and Junko
Oshima. Celular Werner Phenotypes
in Mice Expressing a Putative Dominant-Negative
Human WRN Gene. Genetics
(2000) 154:357 – 362.
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| Medline Accession |
#
10628995 |
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| Tcrb- Vα8.2
Overexpression Model |
MMRRC Strain ID: 0131-H/M
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This mouse model provides
understanding of autoimmunity and intervention
therapy. Specifically, this is a
model for rheumatoid arthritis.
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| Genotype: |
Rearrangement
of Vα11.1 and Vα8.2
TCR chain genes isolated from a T-cell
hybridoma specific for CII using an
internal promoter.
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| Phenotype: |
Rapid onset
of arthritis with sever clinical signs
was detected in transgenic mice after
immunization with CII in complete Freund’s
adjuvant. Histological analysis
of inflamed joints resemble arthritic
human joints.
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| Primary Citation: |
Osman GE, Cheunsuk S, Allen
SE, Chi E, Liggitt HD, Hood LE, Ladiges
WC. Expression of a type II collagen-specific
TCR transgene accelerates the onset of
arthritis in mice. International
Immunology (1998). 10(11): 1613 –
1622.
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| Medline Accession |
#
9846690 |
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Mouse Models Under DevelopmentThe
following mouse models are currently under development
by the Mutant Mouse
Regional Resource Centers (MMRRC) and not yet
ready for distribution. Please contact Heather
Hopkins at hhopkins@u.washington.edu
to request a mouse line directly from our laboratory.
Primary Citation: Ladiges
W, Knoblaugh S, Sopher B, Korth M, MacAuley A, Goodman
A, LeBoeuf R, Katze M. Pancreatic ß cell failure
and diabetes in mice with a deletion mutation of the
endoplasmic reticulum stress response gene P58IPK.
Diabetes, In Review.
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Copyright © 2004
University of Washington. All rights reserved
Sunday December 12, 2004 7:38 PM
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