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Alasdair
MacAuley - Acting Instructor
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Education
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University of Calgary,
Alberta, Canada
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B.S.
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1981 |
Cell Biology & Microbiology |
University
of British Columbia,
Vancouver, B.C |
PhD |
1986 |
Cell Biology |
Positions and Employment
| 1987-1990 |
Postodoctoral
Fellow, Fred Hutchinson Cancer Research Center,
Seattle, WA |
| 1991-1992 |
Postdocotoral
Fellow, University of Washington, Seattle, WA |
| 1992-1997 |
Postdocotoral
Fellow, University of California, San Francisco,
CA |
| 1999 |
Research
Consulting Marketing, Jewish Family Services Agency |
| 1999-2000 |
Research
Associate, Professor Raffi Amit, Chair of the Board,
CreoScitex, Inc., and R.B. Goergen Whartan School
of Business, Philadelphia, PA |
| 2001 |
Research
Scientist, Bioengineering, University of Washington,
Seattle, WA |
| 2002 |
Senior
Fellow, Comparative Medicine, University of Washington, Seattle, WA |
| 2000-present |
Acting Instructor,
Comparative Medicine, University of Washington, Seattle, WA |
Selected peer-reviewed publications
MacAuley,
A., Auersperg,
N. and Pawson, T. (1986). Expression of viral p21ras
during acquisition of a transformed phenotype by adrenal
cortex cells infected with Kirsten murine sarcoma virus.
Mol.Cell.Biol. 6: 342-346.
MacAuley,
A. and Pawson, T. (1988). Cooperative transforming
activities of ras, myc, and src viral oncogenes in nonestablished
rat adrenocortical cells. J.Virol. 62: 4712-4721.
Cooper,
J.A. and MacAuley, A. (1988). Potential positive
and negative autoregulation of p60c-src by intermolecular
autophoosphorylation. Proc.Natl.Acad.Sci. USA
85:4232-4236.
MacAuley,
A. and Cooper, J.A. (1988). The carboxy-terminal
sequence of p561ck can regulate p60c-src. Mol.Cell.Biol.
8: 3560-3564.
Louie,
R.R., King, C.S., MacAuley, A., Marth, J.D.,
Perlmutter, R.M., Eckhart, W. and Cooper, J.A. (1988).
P561ck protein-tyrosine kinase is cytoskeletal and does
not bind to polyomavirus middleT antigen. J.Virol.
62: 4673-4679.
MacAuley,
A. and Cooper, J.A. (1989). Structural differences
between repressed and derepressed forms of p60c-src.
Mol.Cell.Biol. 9:2648-2656.
Kashishian,
A., MacAuley, A. and Cooper, J.A. (1990). Properties
of tripartite chimeras between Src and Lck. Oncogene
5: 1463-1470.
MacAuely,
A. and Cooper, J.A. (1990). Acidic residues at the
carboxy-terminus of p60c-src are required for regulation
of tyrosine kinase activity and transformation. The
New Biologist 2: 828-840. Nada S., Okada, M.,
MacAuley,
A., Cooper, J.A. and Nakagawa, H. (1991). Molecular
cloning of a protein-tyrosine kinase that specifically
phosphorylates a negative-regulatory site of p60c-src.
Nature 351: 69-72.
MacAuley,
A., Okada, M., Nada, S., Nakagawa, H. and Cooper,
J.C. (1992). Phosphorylation of Src mutants at tyr527
in fibroblasts does not correlate with in vitro phosphorlation
by CSK. Oncogene 8: 117-124.
MacAuley,
A., Werb, Z. and Mirkes, P.E. (1993). Characterization
of the unusually rapid cell cycles during gastrulation.
Development 117: 873-883.
Cunningham,
M.L., MacAuley, A. and Mirkes, P.E. (1994). From
gastrulation to neurulation-a transition in retinoic
acid sensitivity identifies distinct stages of neural
patterning in the rat. Developmental Dynamics
200: 227-241.
MacAuley,
A., Cross, J.C. and Werb Z. (1998). Regulation of
the expression of cyclins and molecular markers of trophoblastic
differentiation during the onsent of endoreduplication
in the rat choriocarcinoma cell line, RCHO-01. Mol.Biol.Cell
9:795-807.
MacAuley,
A. and Ladiges, W. Modeling Human Genetic Variation:
Streamlining the Production and Analysis of Human Base
Excision Repair Gene Polymorphisms in Mice. Comparative
Mouse Genomics Center Symposium, Seattle, WA, July,
2002.
Ladiges
W, Wiley J, MacAuley A. Polymorphisms in the
DNA repair gene XRCC1 and age-related disease. Mechanisms
of Ageing and Development, 124: 27-32, 2003.
MacAuley
A, Kemp C, Ladiges WC. Approaches to determine the
clinical significance of genetic variants. In: Single
nucleotide polymorphisms (SNPs): Detection, interpretation,
and application. Mutation Research, In press.
MacAuley A,
Ladiges WC. Approaches to determine clinical significance of
genetic variants. Mutation Research. 2005 Jun 3;573(1-2):205-20.
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