A. Positions and Honors

Positions and Employment

• 1994-2003 Graduate student in Molecular and Cellular Biology, University of Washington, Seattle, WA
• 2000-2003 Graduate student in Biomedical and Health Informatics, University of Washington, Seattle, WA
• 1999-2001 Bioinformatics resource developer and instruction assistant, University of Washington, Seattle, WA
• 2001-2003 Bioinformatics Lead, Seattle Comparative Mouse Genomics Center, University of Washington, Seattle, WA
• 2003-2005 Senior Fellow, Bioinformatics Lead, Seattle Comparative Mouse Genomics Center, University of Washington, Seattle, WA
• 2005-Present Acting Instructor, Bioinformatics Lead, Seattle Comparative Mouse Genomics Center, University of Washington, Seattle, WA

Other Experience and Professional Membership

• 2003- Society for Neuroscience

Honors

• 1990-1994 President’s Scholar
• 1993, 1994 Howard Hughes Student Scholar
• 1994 Graduated Sigma Cum Laude and Phi Beta Kappa
• 1994 Robert C Clarke Honors College graduate
• 1996 Appointment, Molecular and Cellular Biology Training Grant

B. Publications

1. Howe, D. G., Wiley, J. C. & McKnight, G. S. Molecular and behavioral effects of a null mutation in all PKA C beta isoforms. Mol Cell Neurosci20, 515-24. (2002).

2. Kanning, K. H., M; Amieux, PS; Wiley, JC; Bothwell, M; and Schecterson, LC. Proteolytic Processing of the p75 Neurotrophic Receptor and Two Homologs Generates C-Terminal Fragments with Signaling Capacity. Journal of Neuroscience23 (2003).

3. Ladiges, W., Wiley, J. & MacAuley, A. Polymorphisms in the DNA repair gene XRCC1 and age-related disease. Mech Ageing Dev124, 27-32. (2003).

4. McGraw, H. P., KRS; Wiley, JC; and Tublitz NJ. Steriod-Regulated Morphological Plasticity in a Set of Identified Peptidergic Neurons in the Moth Manduca Sexta. Journal of Experimental Biology201, 2981-2992 (1998).

5. Wiley, J. C., Wailes, L. A., Idzerda, R. L. & McKnight, G. S. Role of regulatory subunits and protein kinase inhibitor (PKI) in determining nuclear localization and activity of the catalytic subunit of protein kinase A. J Biol Chem274, 6381-7. (1999).

6. Wiley J.C. , Hudson M., Kanning K.C., Schecterson L.C., and Bothwell M. Familial Alzheimer’s Disease -Secretase Liberation of β-Amyloid Precursor g Mutations Inhibit Protein Carboxy-terminal Fragment. Resubmitted following favorable review, Journal of Neurochemistry.

7. Gennari J, Silberfein A, and Wiley JC. Integrating Genomic knowledge sources through an anatomy ontology. In press, Pacific Symposium of Biocomputing.

8. Wiley JC, Prattipati M, Lin CP, and Ladiges WC. The Comparative Mouse Genomics Centers Consortium Genotype Database. (Manuscript in preparation, requested by Genome Biology).

9. Wiley JC and Bothwell M. Fe65 stimulates -secretase mediated release of the APP intracellular domain. (Manuscript in preparation for the Journal of Neuroscience).

10. Wiley JC, Gunther E, Idzerda R, and Bothwell M. Mice homozygous null for the cAMP protein kinase inhibitor PKI have mild spatial learning impairments. (Manuscript in preparation).