One of five centers across the U.S. collaborating to develop mouse models for studying the biological function of environmentally sensitive DNA repair/cell cycle control gene variants in the human population, and establishing a genetically engineered mouse system as a mammalian model for human functional genomics and single nucleotide polymorphism variant-environment interactions.

Nathan Shock Center of Excellence in Basic Biology of Aging

NIH / National Institute on Aging

07/01/05 - 06/30/10

Ladiges is director of Resource Core A, a program for transgenic animal model development providing state-of-the-art technology for the development of genetically altered rodents in order to advance knowledge about the basic biology of aging.

W.C. Ladiges

04/01/05 – 03/31/10

Ladiges is director of Resource Core 4, a program providing transgenic animal support for the development of new rodent models evaluating gene action in response to environmental influences.

W.C. Ladiges

10/01/03 – 09/30/08

This program project aims to provide a vehicle for a highly integrated series of investigations designed to test theories of aging that emphasize a major role for oxidative damage to DNA, especially mitochondrial DNA, and with an emphasis on the use of genetically altered mice.

Ladiges is leader of Core B, a resource designed to provide animal breeding, maintenance, and phenotyping resources for program research projects and cores with a focus on the WRN gene, genomic instability, and tumorigeneis.

The overall aim is to describe global gene expression profiles for wild-type and transgenic mice and rats and human cell lines exposed to a variety of environmentally-relevant xenobiotics.

W.C. Ladiges

01/01/05 - 12/31/09

A consortium for the determination of public pathways regulating longevity
This consortium will establish an exceptional infrastructure for research into the genetic regulation of aging: a systematic library of yeast strains, worm models and mouse strains and associated databases that will be available to all aging researchers. These will represent a unique resource for study of the genetic elements and pathways whose down-regulation may extend lifespan and health span.

J.C. Wiley

09/01/05 - 08/31/07

Alzheimer’s disease and impaired APP proteolysis
The goal of this proposal is to study the effects of familial Alzheimer’s disease mutations on the gamma-secretase mediated cleavage of APP in the brains of mice using a transgenic reporter mouse model.